PubMed Abstract PMID: 9871636
This abstract also posted in the files section of the K9Kitchen discussion group.

Monica's Comments
This study found that Ellagic acid had the same potency as nalidixic acid (a medication specific to this purpose) in inhibiting E. coli bacteria. Variations of ellagic acid have been synthesized and this study discusses the biological impact of these changes.

The full study is posted as a PDF at Science Direct for a $30 download.

The Abstract
Ellagic acid was found to inhibit E. coli DNA gyrase supercoiling with approximately the same potency as nalidixic acid. Tricyclic analogs of ellagic acid, which vary in the number and position of the hydroxy groups as well as their replacement with halogens, have been synthesized. The biological activity of these analogs is discussed.

Study Authors
Weinder-Wells MA, Altom J, Fernandez J, Fraga-Spano SA,
Hilliard J, Ohemeng K, Barrett JF
R.W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08869, USA

Want to Discuss This Article or Learn More About Canine Nutrition?
Join our group at groups.yahoo.com/group/K9Kitchen/join/