PubMed Abstract PMID: 9690073
This abstract also posted in the files section of the K9Kitchen discussion group.

Monica's Comments
This study looks at ellagic acid's potential to protect the heart. Looking at rats, the study found that lower doses were more effective than higher doses.

Originally published in Eksperimental'naia i Klinicheskaia Farmakologiia, May-June 1998.

The Abstract
The article presents the material on the study of the cardioprotective effect of ellagic acid on a model of neoepinephrine myocarditis in rats. In doses of 0.5-1 mg/kg ellagic acid causes a marked antioxidant effect. Restores the disturbed myocardial functions. The reference-agent vitamin E (50 mg/kg) yields to ellagic acid as a cardioprotector. The effect of 0.5 mg/kg of ellagic acid was more stable than that of a 1 mg/kg dose. The cardioprotective activity of the drugs under study was determined according to the POL parameters in a myocardial homogenate and blood serum and according to the EEG parameters and the degree of cardiomyocyte cytolysis.

Study Authors
Iakovleva LV, Ivakhnenko AK, Buniatian ND; Central Research Laboratory, Ukranian Pharmaceutical Academy, Kharkov, Ukraine

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